Friday, May 14, 2021
Home Business BUSINESS:Hyderabad based Bharat Biotech,Covaxin is one of the leading candidates from India

BUSINESS:Hyderabad based Bharat Biotech,Covaxin is one of the leading candidates from India

Hyderabad based Bharat Biotech, whose Covid-19 vaccine candidate Covaxin is one of the leading candidates from India, will use adjuvant from Kansas based ViroVax for its vaccine to boost immune response and longer lasting immunity.
Vaccines typically use adjuvants to improve the immune response. Adjuvants are pharmacological or immunological agents that improve the immune response of a vaccine.
It may be added to a vaccine to produce more antibodies and longer lasting immunity thus minimising the dose of antigen needed.
An antigen is any substance that causes our immune system to produce antibodies against it.

It can be any substance like chemicals, viruses, bacteria that the immune system does not recognise and tries to fight off.

ViroVax’s alhydroxiquim II adjuvant will be used in Covaxin which is an inactivated Sars-CoV-2 virus vaccine.

The inactivated virus is formulated with ViroVax’s adjuvant to produce the vaccine candidate.

Bharat Biotech is conducting phase II clinical trials in healthy volunteers for Covaxin.

Krishna Ella, chairman and managing director of Bharat Biotech, said, “There is critical need for development and availability of adjuvants that elucidate mechanisms of action inducing greater antibody responses to vaccine antigens, thus resulting in long-term protection against pathogens.

“Adjuvants also enhance the sustainability of the global vaccine supply on account of their antigen-sparing effect.”
He further added that the widely used adjuvant aluminium hydroxide in the development of Sars-CoV-2 vaccines is known to induce Th2 based response.

However, Th2 based response has a theoretical risk of vaccine associated enhanced respiraroty diseases (VAERD or ADE).

“We have used Imidazoquinoline class of adjuvants (TLR7/8 agonists), which are known to induce Th1 based response which further reduces the risk of ADE (Anti-Body Dependent Enhancement).”

In the preclinical studies and animal challenge models (Syrian Hamster and Rhesus Macaques) Bharat Biotech has shown that Covaxin induced Th1 based response.

In response to the Covid-19 pandemic, ViroVax also received supplemental funding for the development of subunit vaccine constructs for the prevention of COVID-19, and for the discovery and development of therapeutics for treating Covid-19.

ViroVax is evaluating a subunit vaccine candidate and has identified potential antiviral therapeutics.

It is currently in the process of testing the efficacy of these compounds.


Please enter your comment!
Please enter your name here

- Advertisment -

Most Popular

The corona warrior is given a cowboy safety kit

Koraput: Kovid fighters working on the Chhattisgarh and Andhra Pradesh border have been provided with various kovid security items by the district emergency office,...

At Kovid Hospital, the young journalist opened up about the food crisis.

A few days back in Malkangiri, the district's Kovid Hospital was accused of negligence and death in treatment, which was denied by the health...

Gajapati District R. Udayagiri Rural Development Department Junior Engineer Corona dies at Berhampur Bada Medical

Paralakhemundi: Prashant Nayak, a junior engineer in the Udayagiri Rural Development Department's office in Gajapati district's Ra Udayagiri, died on Sunday at around 7...

Six people were killed and three others were injured in the lightning strike.

Damanyodi: Two cows and two cows of Lada Chalan and Jhannaguda of Jhanaguda village under Koraput block Dumuripadar panchayat were killed in a lightning...

Recent Comments